Intelligent Labs 5-MTHF Methylfolate 1mg – Quatrefolic® Activated Folate, 120 Capsules

Why Choose Quatrefolic®?

Quatrefolic® represents the 4th generation of folate technology, developed by Gnosis. Unlike older calcium-bound forms such as Metafolin® or L-methylfolate calcium, Quatrefolic® binds the active 5-MTHF molecule to glucosamine. This unique binding enhances solubility and bioavailability, allowing your body to absorb and utilise it more effectively. Each capsule supplies 1 mg of active 5-MTHF in a stable, non-GMO, gluten-free, and animal-free formulation. The glucosamine used is derived from non-shellfish sources, making it suitable for vegetarians and those with shellfish allergies. For individuals with MTHFR gene variants, this form bypasses the liver conversion step, providing immediate usable folate.

Health Benefits of Methylfolate

Folate, in the form of methylfolate, contributes to several normal bodily functions, as recognized by the European Food Safety Authority:

• Reduction of tiredness and fatigue: Folate contributes to normal energy-yielding metabolism.
• Normal homocysteine metabolism: Adequate folate helps maintain healthy homocysteine levels, supporting cardiovascular wellness.
• Normal psychological function: Folate plays a role in neurotransmitter synthesis, supporting mood and mental clarity.
• Normal immune system function: Proper folate status supports immune cell production and activity.
• Maternal tissue growth during pregnancy: Folate is essential for the growth of maternal tissues during pregnancy, making it particularly important for expectant mothers. In line with UK health guidelines, women planning a pregnancy are advised to take a daily folic acid supplement (400 µg) until the 12th week of pregnancy; this product provides a higher dose of the active form suitable for those with MTHFR variants.

This product is a food supplement and should not be used as a substitute for a varied diet and healthy lifestyle. Always read the label before uses.

What Is 5-MTHF Methylfolate?

5-MTHF (5-methyltetrahydrofolate) is the naturally occurring, bioactive form of vitamin B9 – the version your body can immediately put to uses. Unlike synthetic folic acid, which requires enzymatic conversion in the liver, methylfolate is already in its active state. This makes it especially valuable for individuals with genetic variations in the MTHFR gene, which can impair the conversion of folic acid into its usable form. Intelligent Labs 5-MTHF Methylfolate delivers 1,000 mcg (1 mg) of pure Quatrefolic® per capsule.

Who Should Consider This Supplement?

5-MTHF is particularly useful for:

• Individuals with MTHFR gene variants: These genetic differences can reduce the body’s ability to convert folic acid into active folate. Methylfolate bypasses this step, providing the active form directly.
• Women planning pregnancy or during early pregnancy: Adequate folate is essential for foetal neural tube development and maternal tissue growth. This supplement provides the active form for optimal utilisation.
• Those seeking cardiovascular support: By supporting normal homocysteine metabolism, methylfolate may contribute to overall heart health.
• People experiencing fatigue or mood imbalances: Because folate is involved in neurotransmitter and red blood cell production, supplementation may support energy and mood.

Folic Acid vs. Methylfolate: Which Is Better?

Synthetic folic acid (pteroylmonoglutamic acid) is a stable, inexpensive form used in many supplements and fortified foods. However, it must be converted in the body to L-methylfolate—a two-step process that can be inefficient in individuals with MTHFR mutations. Methylfolate (5-MTHF) is the active form, ready for immediate uses. For those with known MTHFR variants or who experience side effects from folic acid (such as unmetabolised folic acid in the bloodstream), methylfolate is generally preferred. The Quatrefolic® form in this supplement offers enhanced bioavailability and gentleness, with many users reporting no stomach discomfort.

Recommended Dosage and Usage

Each capsule contains 1,000 mcg (1 mg) of active 5-MTHF. The recommended serving is one capsule per day with food, or as directed by a health care professional. This 120-capsule bottle provides a 4-month supply at one capsule daily. The tolerable upper intake level for folate from supplements is 1,000 mcg daily for adults. Do not exceed one capsule per day unless under medical supervision. Consult your doctor before uses, especially if you are pregnant, nursing, or taking medication.

Potential Side Effects and Precautions

Methylfolate is generally well tolerated. However, high doses of any folate can mask a vitamin B12 deficiency, which could allow neurological damage to progress unnoticed. If you are at risk for B12 deficiency (e.g., vegans, older adults, or those with pernicious anaemia), consult your health care provider before uses. Some individuals may experience mild digestive upset, sleep disturbances, or increased anxiety when starting supplementation. Starting with a lower dose or taking with food can help. If symptoms persist, discontinue uses and consult a professional.

Quality and Third-Party Testing

Intelligent Labs prioritises purity and potency. Each batch of their 5-MTHF supplement undergoes independent third-party testing for identity, purity, and microbial contaminants. Certificates of analyse are available upon request. The product is manufactured in a GMP-certified facility and is non-GMO, gluten-free, and vegan-friendly.

Frequently Asked Questions

Can I take methylfolate with other B vitamins? Yes, methylfolate works synergistically with vitamin B12 and B6. Many users take it as part of a methylated B-complex.

How long does it take to feel effects? Individual responses vary. Some note improved energy and mood within a few weeks, whilst others may take longer. Consistent daily uses is recommended.

Is this safe during pregnancy? The daily dose (1,000 mcg) is within the recommended intake for pregnancy. However, always consult your obstetrician before starting any supplement.