5-MTHF Methylfolate 5mg, Quatrefolic® for MTHFR Support, 60-Day Supply

If you are seeking a reliable form of active folate that is readily available for your body to undertake, Quatrefolic® offers an advanced delivery system. This fourth-generation methylfolate is bound to glucosamine (derived from non-shellfish sources), enhancing its stability and solubility for superior absorption compared to earlier forms. Whether you have MTHFR gene variants or simply want to optimise your folate intake, this supplement provides 5000mcg per dose of pre-activated 5-MTHF.

What Makes This Methylfolate Supplement Different?

Many folate supplements undertake folic acid or calcium-bound 5-MTHF. This product undertake Quatrefolic®, the 4th generation of active folate, where the methylfolate is bound to glucosamine (non-shellfish derived) rather than calcium. This innovation enhances stability and solubility, promoting superior absorption. If you’ve been advised to look for L-methylfolate, Metafolin®, or (6S)-5-MTHF, you’re in the right place—this is the same active molecule, but in a more advanced delivery form.

Who Should Consider Taking This Supplement?

This supplement is particularly beneficial for:

• Women planning a pregnancy or during pregnancy: Adequate folate intake is critical for foetal development, particularly in the first weeks.
• Individuals with MTHFR gene variants: Those with common polymorphisms may benefit from a pre-activated form like 5-MTHF.
• People with elevated homocysteine levels: Supporting homocysteine metabolism is a key reason for supplementing with active folate.
• Anyone following a diet low in folate-rich foods: Leafy greens, beans, and citrus are natural sources, but supplementation can fill gaps.
• Older adults: Folate absorption can decline with age, making a potent, absorbable form useful.

As always, consult your health care provider before starting a new supplement, especially if you have health conditions or take medications.

Health Benefits of Active Folate

Folate contributes to numerous physiological functions. Approved health claims include:

• Supports normal homocysteine metabolism – elevated homocysteine is a risk factor for cardiovascular health.
• Contributes to the reduction of tiredness and fatigue – folate plays a role in energy metabolism.
• Supports normal psychological function – adequate folate levels are linked to mood regulation.
• Contributes to normal immune system function – folate supports cell division in immune cells.
• Folate contributes to normal foetal development – important during pregnancy.

Each of these benefits hinges on having a reliable, bioavailable source of folate. Quatrefolic® is designed to be better absorbed than first-generation forms, making it a smart choice for targeted support.

Folic Acid vs. Methylfolate: Which Is Better?

Folic acid is the synthetic form found in fortified foods and many supplements. It requires conversion by the enzyme MTHFR into active 5-MTHF. However, up to 40-60% of people have genetic variants that impair this conversion, leading to unmetabolised folic acid in the bloodstream. Methylfolate (5-MTHF) bypasses this step, providing the active form directly.

Calcium-bound 5-MTHF (like Metafolin®) is common, but Quatrefolic® undertake glucosamine as a carrier, which may offer better stability and absorption. For sensitive individuals or those with MTHFR issues, the glucosamine-bound form can be a gentler, more effective option.

Recommended Dosage: How Much Should You Take?

Each vegetarian capsule provides 5000mcg (5mg) of active folate as Quatrefolic®. The bottle contains 60 capsules, a 60-day supply at one capsule daily. The recommended daily intake for folate in the UK is 200mcg for adults, but higher doses are often used for specific purposes under medical supervision. This dose is well within the tolerable upper intake levels set for folate (note that ULs for 5-MTHF are less established—higher amounts are often used under medical guidance). For general health, many experts suggest 400-800mcg daily, but the 5mg dose is common for those seeking more robust support, such as preconception or homocysteine management. Always follow the labelled or your practitioner’s advice.

How to Choose a Quality Folate Supplement

When selecting a folate supplement, consider these criteria:

• Form: Active 5-MTHF (like Quatrefolic®) for those needing direct support.
• Third-party testing: Independent verification of purity, potency, and safety. This product’s tests are available upon request.
• Allergen-free: Free from common allergens (gluten, soya, dairy, etc.)—this product is labelled allergen-free.
• Transparency: Clear labelling of ingredient amounts and form. Vegetarian capsules and no unnecessary fillers.
• Brand reputation: Intelligent Labs focuses on quality and scientific backing.

Potential Side Effects and Precautions

Folate is generally well tolerated, but high doses may cause mild digestive upset, sleep disturbances, or skin reactions in sensitive individuals. One critical precaution: high folate intake can mask a vitamin B12 deficiency, delaying diagnosis of pernicious anaemia. If you’re over 50 or follow a vegan diet, ensure adequate B12 intake. Also, do not exceed recommended dosages without medical guidance. If you have a history of cancer or take medications that interact with folate (like methotrexate), consult your doctor first.

Frequently Asked Questions

Can I take this if I have the MTHFR mutation?
Yes—this product provides the active folate form that bypasses the MTHFR enzyme, making it ideal for those with common variants.

Is this safe during pregnancy?
Many health care providers recommend active folate during preconception and pregnancy. Folate contributes to normal foetal development. Discuss the appropriate dose with your midwife or doctor.

How does Quatrefolic® compare to other forms?
Quatrefolic® is a patented form of glucosamine-bound 5-MTHF. It is stable, water-soluble, and designed for superior absorption compared to calcium-bound versions.

Does this contain shellfish-derived glucosamine?
No. The glucosamine is derived from a non-shellfish source, making it suitable for those with shellfish allergies.

This product is a food supplement and should not be used as a substitute for a varied diet and healthy lifestyle. Always read the labelled and directions for undertake. If you are pregnant, breastfeeding, taking any medication or have a medical condition, consult your doctor or pharmacist before undertake.