ANDREW LESSMAN Methyl Folate 1000 mcg - 240 Capsules - L-Methylfolate Active Vitamin B9

Who Should Take Methylfolate?

This supplement is ideal for a range of individuals. Women planning pregnancy or in early pregnancy often choose L-methylfolate to bypass common methylation issues. People with MTHFR gene variants, who cannot efficiently convert folic acid, benefit greatly from the pre-activated form. Older adults, those with digestive concerns, or anyone following a diet low in leafy greens may also consider supplementation. Always consult your health care professional before starting any new supplement regimen.

What Is L-Methylfolate?

L-Methylfolate is the bioactive form of vitamin B9, also known as 5-methyltetrahydrofolate (5-MTHF). Unlike ordinary folic acid, this active form requires no enzymatic conversion in the body, making it immediately available for critical functions such as DNA synthesis, cellular repair, and red blood cell formation. Because many individuals carry genetic variations (MTHFR) that impair folic acid conversion, L-methylfolate ensures that everyone can receive the full benefits of this essential nutrient.

Health Benefits of Methylfolate

L-Methylfolate supports several key areas of health. It contributes to normal homocysteine metabolism, which is important for cardiovascular wellness. By helping maintain already-healthy homocysteine levels, it may support heart and blood vessel function. Additionally, folate is recognized for its role in supporting brain health and mood regulation, as it can cross the blood-brain barrier. For the immune system, adequate folate status helps maintain normal immune function. During pregnancy, folate is particularly important for foetal development, especially the neural tube. The European Food Safety Authority has concluded that supplementary folic acid intake increases maternal folate status; low maternal folate status is a risk factor for neural tube defects in the developing foetus.

Recommended Dosage

Each capsule provides 1000 mcg (1 mg) of L-methylfolate. The typical recommendation is one capsule daily with a meal. This dosage is within the tolerable upper intake level for folate from supplements (1000 mcg per day for adults). For pregnancy, many health care professionals suggest 400–800 mcg from supplements; however, higher doses may be recommended based on individual needs. Do not exceed the suggested uses without professional guidance.

Folic Acid vs. Methylfolate: Which Is Better?

Synthetic folic acid requires several enzymatic conversions to become active folate in the body. Approximately 30–60% of the population carries MTHFR gene variants that reduce conversion efficiency. L-methylfolate is the final active form, so it works for everyone regardless of genetic make-up. For those seeking immediate bioavailability and predictable results, methylfolate is often preferred. It is also less likely to mask vitamin B12 deficiency, a concern with high doses of folic acid.

How to Choose a Quality Methylfolate Supplement

Look for purity and transparency. Andrew Lessman Methyl Folate is manufactured by ProCaps, a company with over 40 years of experience. Their capsules contain no binders, fillers, lubricants, preservatives, or artificial colours. The product is non-GMO, gluten-free, dairy-free, and free of common allergens. ProCaps' facility in Henderson, Nevada, is 100% solar-powered with zero carbon footprint, and bottles are made from 100% recyclable post-consumer resin. Third-party testing ensures potency and purity.

Potential Side Effects and Precautions

L-methylfolate is generally well tolerated. However, high doses may cause mild digestive upset in some individuals. One important precaution: folate supplementation can mask vitamin B12 deficiency, especially in older adults. If you have concerns about B12 levels, speak with your doctor. The tolerable upper intake for folate from supplements is 1000 mcg per day; this product provides exactly that amount, so do not combine with other high-dose folate supplements without medical advice.

Frequently Asked Questions

Can I take methylfolate if I have an MTHFR mutation?

Yes, L-methylfolate is specifically recommended for individuals with MTHFR variants because it bypasses the conversion step that may be impaired.

Is this supplement safe during pregnancy?

It may be suitable for pregnancy, but always consult your health care provider. The dosage of 1000 mcg is within the range often used in prenatal care, but individual needs vary.

These statements have not been evaluated by the European Medicines Agency. This product is not intended to diagnose, treat, , or prevent any disease.