Key Health Benefits
Bone Health: Vitamin D3 helps the body absorb calcium and phosphorus, contributing to the maintenance of normal bones. Vitamin K2 activates osteocalcin, which binds calcium to the bone matrix, supporting bone density.*
Cardiovascular Support: Vitamin K2 activates matrix GLA protein (MGP), which helps prevent calcium deposition in blood vessels, contributing to normal blood coagulation and vascular health.*
Immune Function: Vitamin D3 is essential for the normal function of the immune system, helping to maintain a healthy defence against infections.*
Healthy Ageing: The inclusion of geranylgeraniol (GG) supports the body's natural production of CoQ10 and vitamin K recycling, which decline with age, promoting cellular energy and vitality.*
Mood and Wellbeing: Adequate vitamin D levels are associated with a positive mood and emotional balance, especially during darker months.*
Why Take Vitamin D3 and K2 Together?
Vitamin D3 and K2 work as a team. D3 enhances calcium absorption from the gut, while K2 directs that calcium to the bones and teeth, preventing it from accumulating in soft tissues like arteries. This synergy is why many health-conscious individuals choose a combined D3 and K2 supplement.
Designs for Health Vitamin D Supreme goes a step further by including both vitamin K1 and K2 (as MK-4) along with GG, a naturally occurring compound that supports healthy ageing. This comprehensive formula is designed to promote strong bones, cardiovascular health, immune resilience, and overall wellbeing.*
Understanding the Synergy: How D3 and K2 Work Together
Vitamin D3 (cholecalciferol) stimulates the production of calcium-binding proteins in the gut, enhancing calcium absorption. Vitamin K2 (menaquinone) then activates two crucial proteins: osteocalcin, which binds calcium to the bone matrix, and matrix GLA protein (MGP), which helps keep calcium from depositing in blood vessels.*
This teamwork ensures calcium is used effectively for strong bones whilst maintaining arterial flexibility. The MK-4 form of K2 is particularly well-studied for bone health and is often preferred for its rapid action in tissues. With 2000 mcg of total vitamin K (as K1 and MK-4), this formula provides a clinically relevant amount to support these pathways.
What to Look For in a D3 + K2 Supplement
When choosing a vitamin D3 and K2 supplement, consider the form and dosage. Vitamin D3 (cholecalciferol) is the most bio-available form. For K2, look for MK-4 or MK-7; this product uses MK-4, which has a shorter half-life but is well-researched for bone health. The dosage of 5000 IU D3 and 2000 mcg K (combined K1 and MK-4) provides a robust amount for most adults, whilst individual needs vary.
Purity and third-party testing are also important. Designs for Health is a trusted practitioner brand, often recommended by functional medicine professionals. Their supplements are manufactured in cGMP-certified facilities and undergo rigorous quality checks.
If you follow a specific diet, note that this formula is not vegan (D3 from lanolin), but it is free from common allergens like gluten, dairy, and soya.
Recommended Dosage
One capsule of Vitamin D Supreme provides 5000 IU of vitamin D3 and 2000 mcg of vitamin K (as K1 and MK-4). This dosage is suitable for adults looking to maintain healthy vitamin D and K levels. As with any supplement, it is best to consult your GP before starting a new regimen, especially if you have underlying health conditions or are taking medications.
To maximise absorption, take the capsule with a meal that contains some fat. Consistency is key for maintaining steady levels.
Frequently Asked Questions
Can I take vitamin D3 and K2 if I am on blood thinners? If you take warfarin (Coumadin) or other anticoagulants, consult your GP before taking vitamin K supplements, as K can interfere with these medications.
What is the best time to take this supplement? Vitamin D3 and K2 are fat-soluble, so taking them with a meal containing fat enhances absorption. Many people take it with breakfast or lunch.
How many capsules per day? The recommended serving is one capsule daily, providing 5000 IU D3 and 2000 mcg K.
Is it safe to take 5000 IU of vitamin D every day? For most adults, 5000 IU is within a safe range, but it is wise to check your vitamin D levels with a health care provider to determine your individual needs.
Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended dose. If you are on medication, consult your GP before uses. These statements have not been evaluated by the EFSA. This product is not intended to diagnose, treat, , or prevent any disease.