Top Features to Look For
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pH-sensitive HPMCP coating – disintegrates at pH 5.5+ for intestinal release
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Plant-based composition – 60% HPMC, 40% HPMCP, no animal gelatine
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Size 0 – versatile capacity for many powder formulations
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White colour – neutral appearance suitable for labelling
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GMP certified manufacturing – ensures quality and consistency
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Pre-joined capsules – ready for filling, easy to handle
Who Should Uses These Empty Capsules?
These empty enteric coated capsules are ideal for supplement manufacturers, compounding pharmacies, and DIY enthusiasts who want to create their own enteric-release supplements. They are particularly useful for filling with probiotics, digestive enzymes, omega-3 oils (to reduce fish burps), garlic extract, and other ingredients that benefit from intestinal release. Individuals who follow a vegetarian or vegan lifestyle will appreciate the plant-based composition. Whether you are formulating small batches for personal uses or large-scale production, these capsules provide a reliable delivery system.
Key Benefits of Using Enteric Capsules
Using enteric coated capsules offers several advantages for both manufacturers and end users. Protection from stomach acid is the primary benefit—active ingredients that are degraded by low pH can survive transit through the stomach. Additionally, these capsules reduce stomach irritation for compounds that may cause discomfort when released in the stomach. The precision of pH-dependent release also supports consistent release in the small intestine, helping to optimise active ingredient delivery. Because the capsules are made from plant-derived HPMC and HPMCP, they are suitable for vegetarian and vegan formulations. Each capsule is manufactured under GMP standards, ensuring consistent quality and performance.
What Are Enteric Coated Capsules?
These empty enteric coated capsules are specially designed to protect sensitive ingredients from stomach acid. They are made from a pH-sensitive polymer blend: 60% HPMC (hydroxypropyl methylcellulose) and 40% HPMCP (hydroxypropyl methylcellulose phthalate). The HPMCP coating ensures that the capsule shell remains intact in the acidic environment of the stomach (pH below 5.5) and only begins to disintegrate when it reaches the higher pH of the small intestine (pH 5.5 or above). This targeted release mechanism is ideal for delivering probiotics, enzymes, or other pH-sensitive nutrients directly to the intestinal tract.
How to Choose the Right Empty Capsules
When selecting empty capsules, consider size, composition, and coating. Size 0 is one of the most popular sizes, holding approximately 0.68 ml of powder (depending on density). The capsule composition matters: HPMC-based capsules are vegetarian, while gelatine capsules are animal-derived. Here, the enteric coating is achieved with HPMCP, a cellulose-based polymer that meets pharmaceutical standards. Look for capsules that conform to GMP guidelines and have consistent wall thickness to ensure reliable dissolution. These capsules are joined (pre-locked), saving time during filling—whilst they can be separated for manual filling if needed.
FAQs About Enteric Coated Capsules
What is the difference between enteric coated and regular capsules?
Regular capsules dissolve quickly in stomach acid, while enteric coated capsules resist acidic conditions and break down only in the higher pH of the small intestine. This protects acid-sensitive ingredients.
Can these capsules be used for liquid fills?
These capsules are designed for powder fills. Liquid or oil fills may compromise the integrity of the HPMC/HPMCP shell. For liquid formulations, consider other capsule types.
How should these capsules be stored?
Store in a cool, dry place away from direct sunlight. Avoid humidity to prevent premature softening or sticking. Typically, a temperature below 25°C (77°F) with relative humidity under 60% is recommended.
Are these capsules suitable for vegans?
Yes, both HPMC and HPMCP are plant-derived cellulose compounds, making these capsules suitable for vegetarian and vegan uses.
This product is not intended to diagnose, treat, or prevent any disease. Always read the label and follow directions for uses.