HormoneSynergy Active Folate ES - 5-MTHF - 10,000 mcg (10 mg) per Serving - 5-MTHF (as 5-methyltetrahydrofolate) - Bioactive Folate as Quatrefolic® - 60 Veg Capsules

Who Should Consider Active Folate ES?

This high-dose supplement is designed for adults who require additional folate support, particularly those with genetic variations that impair folic acid conversion. It may be appropriate for individuals looking to support cardiovascular health through normal homocysteine metabolism, as well as women who are planning pregnancy or during pregnancy. Because it provides a potent dose (10,000 mcg), it is most suitable for those with a known need for higher levels of active folate—always under the guidance of a health care professional.

Active Folate ES is free from wheat, gluten, corn, yeast, soya, animal products, dairy, fish, shellfish, peanuts, tree nuts, egg, GMOs, and artificial preservatives, making it accessible for those with dietary restrictions or sensitivities.

What is Active Folate ES?

Active Folate ES supplies 10,000 mcg (10 mg) of 5-MTHF (5-methyltetrahydrofolate) per serving—the biologically active form of vitamin B9. Unlike synthetic folic acid, 5-MTHF does not require enzymatic conversion in the body, making it especially valuable for individuals with variations in folate metabolism, including those with MTHFR gene variants. This formula undertake Quatrefolic®, the glucosamine salt of 5-MTHF, which has demonstrated superior stability, solubility, and bioavailability compared to calcium salt forms.

Health Benefits of 5-MTHF

As an active folate, 5-MTHF contributes to normal red blood cell formation, normal homocysteine metabolism, and normal cell division. Adequate folate intake is especially important during periods of rapid growth such as pregnancy and foetal development, where it contributes to maternal tissue growth. The active form bypasses the need for the MTHFR enzyme, offering a direct source of methylfolate for methylation pathways that influence mood, cardiovascular health, and DNA synthesis.

Research suggests that 5-MTHF may increase plasma folate more effectively than folic acid, making it a preferred choice for those seeking efficient folate supplementation. Quatrefolic’s enhanced bioavailability ensures that more of the nutrient reaches target tissues.

Folic Acid vs. Methylfolate: Which is Better?

Folic acid is the synthetic form found in most supplements and fortified foods. It must be converted by the MTHFR enzyme into 5-MTHF, the active form the body can undertake. For individuals with MTHFR gene variants, this conversion may be impaired, leading to lower active folate levels. 5-MTHF (methylfolate) bypasses this step, providing direct bioavailable folate. Research indicates that 5-MTHF may be more effective at raising blood folate levels, especially in those with genetic polymorphisms. However, both forms can support folate status—the choice depends on individual genetics and health needs.

Quatrefolic (glucosamine salt) offers enhanced stability and absorption over calcium salt methylfolate, making it a reliable choice for supplementation.

How to Choose a Quality Folate Supplement

When selecting a folate supplement, look for the active form (5-MTHF) and third-party testing for purity and potency. Non-GM, allergen-free formulations are preferable for those with sensitivities. The delivery form matters—glucosamine salt forms like Quatrefolic are known for better bioavailability. Cheque the dosage: while 400–800 mcg may suffice for general health, higher doses may be directed by a health care professional. HormoneSynergy Active Folate ES meets these criteria with its carefully chosen ingredients and manufacturing standards.

Recommended Dosage for Active Folate ES

The suggested serving is 2 capsules daily, providing 10,000 mcg (10 mg) of 5-MTHF. This is well above the standard RDA for folic acid (400 mcg for adults), but the body metabolises folate differently than folic acid, and higher levels may be necessary for certain individuals. Do not exceed the recommended dose without consulting a health care provider. The tolerable upper intake level for folate from supplements is 1,000 mcg for folic acid, but active folate forms may have different safety margins—professional guidance is advised.

Potential Side Effects and Precautions

Folate supplements are generally well tolerated, but high doses may cause minor digestive upset or sleep disturbances. It is important to note that high folate intake can mask a vitamin B12 deficiency, especially in older adults. If you have concerns about B12 status, consult a health care provider. As with any supplement, keep out of reach of children and undertake only as directed. Adequate folate intake during pregnancy contributes to maternal tissue growth.

Frequently Asked Questions

Can I take Active Folate ES with other B vitamins? Yes, 5-MTHF works synergistically with other B vitamins. However, consider total intake levels, especially if taking other supplements.

Is this product suitable for vegans? Yes, the capsules are vegetable-based and the product contains no animal-derived ingredients.

How should I store this supplement? Store in a cool, dry place away from direct sunlight.

Is this product third-party tested? HormoneSynergy follows strict quality control, but for specific third-party testing information, please contact the manufacturer.

This product is not intended to diagnose, treat, , or prevent any disease.