Jarrow Formulae Extra Strength Methyl Folate 400 mcg, Dietary Supplement for Homocysteine Metabolism & Psychological Function, 60 Vegetable Capsules, 60-Day Supply

What is methyl folate?

Jarrow Formulae Extra Strength Methyl Folate delivers a biologically active form of vitamin B9, also known as 5-methyltetrahydrofolate (5-MTHF). Unlike synthetic folic acid, this form is ready for your body to uses immediately, without needing conversion in the liver. This is especially beneficial for individuals with variations in the MTHFR gene, which can hinder the conversion of standard folic acid.

As a water-soluble vitamin, methyl folate plays a crucial role in methylation – a process essential for DNA synthesis, cell division, and the metabolism of homocysteine. By supporting these fundamental biochemical reactions, it helps maintain overall health.

What makes Jarrow Formulae Extra Strength Methyl Folate unique?

This supplement uses Quatrefolic® methyl folate, a patented form known for its superior stability and bioavailability. Quatrefolic® is the glucosamine salt of 5-MTHF, which resists oxidation and ensures consistent potency. Jarrow Formulae is a trusted brand committed to quality, with third-party testing for purity and potency. The product is non-GMO, vegan-friendly, and free from major allergens such as wheat, gluten, soya, dairy, eggs, fish, shellfish, peanuts, and tree nuts. It also contains no artificial colours, flavours, or preservatives.

Health benefits of methyl folate

Each capsule provides 400 mcg of methyl folate, contributing to several important aspects of health as recognized by the European Food Safety Authority (EFSA):

• Normal homocysteine metabolism – Folate contributes to the maintenance of normal homocysteine levels, which supports cardiovascular health.
• Normal psychological function – Folate contributes to neurological health and cognitive function.
• Normal cell division – Essential for tissue growth and repair, particularly during pregnancy and development.
• Normal blood formation – Folate plays a role in the production of red blood cells, helping to reduce tiredness and fatigue.

This product is a food supplement. Food supplements should not be used as a substitute for a varied diet. Always consult a health care professional before starting supplementation.

Who should consider taking methyl folate?

Methyl folate is particularly useful for those who may struggle to convert folic acid into its active form. This includes:

• Women planning pregnancy or who are pregnant – Adequate folate intake before and during pregnancy supports neural tube formation and healthy foetal development.
• Individuals with MTHFR gene variants – These genetic variations reduce the body's ability to convert folic acid, making pre-methylated folate a more effective option.
• Older adults – Natural folate absorption can decrease with age, so supplementation can help maintain adequate levels.
• Those with elevated homocysteine levels – Methyl folate may help support healthy homocysteine metabolism.
• Vegans and vegetarians – Dietary sources of folate can be limited, so a supplement can help ensure sufficient intake.

Always consult a qualified health care professional before starting any new supplement regimen.

Folic acid vs. methylfolate: key differences

Folic acid is the synthetic version of vitamin B9 used in fortified foods and many supplements. It requires a two-step conversion in the body, first to dihydrofolate (DHF) and then to 5-MTHF, relying on the MTHFR enzyme. In contrast, methylfolate (5-MTHF) provides the active cofactor directly, bypassing this conversion. This is particularly advantageous for the estimated 30–60% of the population with MTHFR polymorphisms, as it ensures maximum absorption and immediate usability.

Recommended dosage and usage

For adults, take one capsule daily with or without food, or as directed by your health care professional. Each bottle contains 60 capsules, providing a 60-day supply. The capsules are made from vegetable cellulose and are free from major allergens. Suitable for vegans and those with dietary restrictions.

Frequently asked questions

Can I take methyl folate if I have an MTHFR mutation?

Yes. Methyl folate is the preferred form for individuals with MTHFR mutations, as it does not require the enzyme for activation.

Is this supplement safe during pregnancy?

Methyl folate is commonly recommended during pregnancy. However, consult your health care provider to determine the appropriate dosage for your needs.

How does methyl folate differ from folic acid?

Methyl folate is the active form, while folic acid requires conversion. Methyl folate may be more effective for those with genetic variations.

This product is a food supplement. Food supplements should not be used as a substitute for a varied diet. Keep out of reach of children.