Kirkman DMG 125 mg with Folate and Methyl B12 – Hypoallergenic Formula, 100 Capsules

Key Benefits of DMG, Folate, and Methyl B12

Supports Methylation and Methionine Metabolism: DMG provides methyl groups that help convert homocysteine to methionine, an important amino acid for protein synthesis and cardiovascular health. Folate and vitamin B12 act as cofactors in this process, promoting efficient methylation.
Immune Function: DMG has been studied for its role in supporting the normal function of the immune system, particularly during times of stress. By enhancing the activity of natural killer cells and macrophages, it helps the body maintain a healthy defence system.
Energy Production and Reduction of Tiredness: Through its involvement in the Krebs cycle and carnitine synthesis, DMG contributes to cellular energy generation. Combined with vitamin B12, which contributes to normal energy-yielding metabolism and the reduction of tiredness and fatigue, this supplement helps combat fatigue.
Neurological Health: Methyl B12 is essential for myelin sheath maintenance and nerve transmission. Folate and B12 together support normal psychological function and cognitive health.

Who Can Benefit from This Supplement?

This formula is ideal for individuals seeking targeted support for methylation and immune function. People with variations in the MTHFR gene may particularly benefit from the 5-MTHF form of folate, which bypasses the need for conversion in the body. Additionally, those following a vegan or vegetarian diet often require supplementary B12, and the methylcobalamin form here is a bioactive option. The hypoallergenic formulation—free from gluten, casein, and artificial additives—makes it suitable for individuals with sensitivities or allergies. Kirkman's "Ultra Tested" programme ensures purity and potency, giving you confidence in every capsule.

What Is DMG and Why Combine It with Folate and Methyl B12?

Dimethylglycine (DMG) is a naturally occurring amino acid derivative that plays a vital role in the body's methylation cycle. Methylation is a biochemical process essential for DNA repair, detoxification, and neurotransmitter production. However, DMG requires folate to function optimally—it donates methyl groups that attach to folate to form methylene tetrahydrofolate, a key intermediate in many metabolic pathways. This supplement combines 125 mg of DMG with folate (as 5-MTHF, the bioactive form) and methylcobalamin (vitamin B12) to ensure that the methylation cycle runs smoothly. Folate can mask a vitamin B12 deficiency, so including methyl B12 helps maintain a healthy balance.

How to Choose the Right DMG Supplement

Not all DMG supplements are created equal. Look for a product that includes the bioactive forms of folate (5-MTHF) and B12 (methylcobalamin) for maximum absorption. This Kirkman formula is hypoallergenic, made with plant-based capsules, and verified through third-party testing—no gluten, casein, or common allergens. The inclusion of both folate and B12 ensures that DMG can work biochemically as intended, making it a comprehensive choice for methylation support. Always check the ingredients list to confirm it meets your dietary needs and quality standards.

Recommended Dosage and How to Take

As a food supplement, take one capsule daily with food or as directed by your health care professional. Capsules are plant-based and easy to swallow. Since individual needs vary—especially for those with specific genetic or health considerations—it is wise to consult a practitioner before starting any new supplement regimen. Store in a cool, dry place and keep out of reach of children. Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.

Frequently Asked Questions

What is 5-MTHF and why is it used?
5-MTHF (methylfolate) is the active form of folate that the body can uses directly. Many people have difficulty converting folic acid to its active form due to genetic variations, making 5-MTHF a superior choice.

Why methylcobalamin instead of cyanocobalamin?
Methylcobalamin is the naturally occurring, bioactive form of vitamin B12. It is better utilised by the body, especially for neurological health and methylation processes.

Can I take this if I am pregnant or nursing?
If you are pregnant, nursing, or have a medical condition, consult your health care provider before uses.

Does this supplement contain common allergens?
This product is hypoallergenic: gluten-free, casein-free, and made without artificial colours or preservatives. Capsules are plant-based.

• DMG 125 mg per capsule
• Folate (as 5-MTHF) and Methyl B12 included
• Hypoallergenic – gluten and casein free
• Plant-based capsules
• Ultra Tested for purity and potency
• Supports methylation, immune function, and energy metabolism

Usage Instructions: Take one capsule daily with food, or as recommended by your health care professional. Do not exceed suggested uses. This product is a food supplement and is not intended to diagnose, treat, , or prevent any disease.

These statements have not been evaluated by the Food Standards Agency. This product is not intended to diagnose, treat, , or prevent any disease.