L-Methylfolate 15 mg - 180 Capsules (2 Bottles) - Professional Strength Active Methyl Folate - 5-MTHF Supplement

Who Might Benefit from a 5-MTHF Supplement?

Ensuring adequate folate intake is important for everyone, but certain groups may find L-methylfolate particularly beneficial. Individuals with MTHFR gene variations, which affect up to 40–60% of the population, have a reduced ability to convert folic acid into the active form. Taking L-methylfolate bypasses this conversion step, providing the body-ready form directly. Women planning pregnancy or expecting are often advised to take folic acid, but L-methylfolate may be a superior choice, especially for those with MTHFR. People on certain medications such as methotrexate or anticonvulsants, which can interfere with folate metabolism, may also benefit. Older adults, whose digestive changes can reduce absorption, and those with elevated homocysteine levels may find active folate helpful. Always consult a health care professional to determine the appropriate dosage for your needs.

What Is L-Methylfolate and Why Is It Important?

Folate, also known as vitamin B9, is an essential nutrient that supports DNA synthesis, cell division, and red blood cell formation. L-methylfolate (5-MTHF or 5-methyltetrahydrofolate) is the biologically active form of folate that the body can uses immediately, unlike synthetic folic acid which requires conversion by the liver. This is particularly valuable for individuals with MTHFR gene variants that impair conversion. Our supplement delivers 15 mg (15,000 mcg) of pure L-methylfolate per capsule, sourced from calcium L-methylfolate (Metafolin® or equivalent). With 180 capsules per package (2 bottles of 90), this provides a 180-day supply at one capsule daily.

L-Methylfolate vs. Folic Acid: What’s the Difference?

The main difference lies in metabolism. Folic acid is a synthetic form that must undergo a two-step enzymatic conversion in the liver to become active, with the final step relying on the MTHFR enzyme. People with common genetic variants have reduced efficiency in this step. L-methylfolate is already active and does not require conversion. Choosing L-methylfolate over folic acid offers several advantages: it is directly usable by the body, may be more effective for those with MTHFR mutations, and does not lead to accumulation of unmetabolised folic acid, which has been a concern with high intakes of synthetic folic acid. For the most bio-available form of folate, L-methylfolate is an excellent choice.

Health Benefits of Active Folate Supplementation

Folate contributes to several vital functions. EFSA-approved health claims include: folate contributes to normal homocysteine metabolism (in combination with vitamins B12 and B6); normal psychological function; normal blood formation; normal function of the immune system; and reduction of tiredness and fatigue. Folate also has a role in cell division and maternal tissue growth during pregnancy. Adequate folate intake is essential for everyone, and L-methylfolate provides a direct source of this important nutrient.

How to Choose a Quality Methylfolate Supplement

Not all supplements are the same. Look for the form calcium L-methylfolate (Metafolin® or Quatrefolic®) to ensure stability and bioavailability. Our supplement is filler-free, uses only Non-GMO ingredients, and is manufactured in a cGMP-compliant facility in the USA. Third-party testing guarantees potency and purity. It is free from gluten, wheat, yeast, milk, lactose, soya, artificial flavours, colours, and preservatives, making it suitable for most dietary restrictions.

Recommended Dosage and Usage

Each capsule provides 15 mg (15,000 mcg) of L-methylfolate, a high-dose designed for individuals with increased needs, such as those with MTHFR variants or under medical supervision. The typical over-the-counter dose is 400–800 mcg, so this product is significantly stronger. Suggested uses: take one capsule daily with a meal and water, or as directed by your health care provider. Do not exceed the recommended dose. This package contains 2 bottles of 90 capsules, providing a 6-month supply at one per day.

Potential Side Effects and Precautions

L-methylfolate is generally well tolerated, but some individuals may experience mild digestive upset, nausea, or bloating. Rarely, high doses can mask a vitamin B12 deficiency, particularly in older adults. If you have pernicious anaemia or suspect B12 deficiency, consult your doctor before uses. Do not take if you are allergic to any ingredient. Keep out of reach of children. This product is a food supplement and should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.

Frequently Asked Questions

Can I take L-methylfolate if I don’t have MTHFR? Yes, it is safe and effective for anyone needing folate, whilst a lower dose may be sufficient. Always consult a health care professional.

Is 15 mg too much? For most people, this dose exceeds standard dietary requirements. It is typically used under medical guidance for specific conditions. Check with your practitioner.

How does this compare to folic acid 400 mcg? 15 mg is 37.5 times the common 400 mcg folic acid dose, and L-methylfolate is more directly usable.

Are these capsules easy to swallow? Yes, they are a small 4V size for easy swallowing.

This product is a food supplement. Do not exceed stated dose. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Always consult your doctor before taking any supplement, especially if you are pregnant, breastfeeding, or on medication.