Life Extension BioActive Folate & Vitamin B12 - 90 Capsules

Key Benefits of BioActive Folate and B12

Maintaining healthy homocysteine levels is vital for cardiovascular and cognitive wellbeing. Folate and vitamin B12 contribute to normal homocysteine metabolism, which in turn supports heart and brain health. These nutrients also play a role in normal psychological function and the reduction of tiredness and fatigue. Additionally, folate and B12 are involved in red blood cell formation, ensuring efficient oxygen transport throughout the body. By providing the active forms of these B vitamins, this formula helps maintain DNA integrity and supports the normal function of the immune system. When taken as part of a varied diet, it helps fill nutritional gaps that can affect mood, memory, and overall vitality.

Why Choose the Active Forms?

Many supplements contain folic acid and cyanocobalamin, synthetic forms that require enzymatic conversion in the body. For a significant portion of the population, this conversion is inefficient due to genetic variations, age, or digestive issues. Life Extension's BioActive Folate & Vitamin B12 delivers 5-MTHF and methylcobalamin, which are already in the form your cells can uses. This means faster absorption and more predictable benefits, especially for methylation support. Methylcobalamin is also considered superior to cyanocobalamin for neurological health because it is retained in tissues longer and directly participates in the methylation cycle. By choosing the active forms, you avoid the potential accumulation of unmetabolised synthetic folic acid and ensure your body gets the nutrients it needs without extra metabolic steps. This is particularly important for those with MTHFR mutations, who may have difficulty converting folic acid to the active form.

What Is BioActive Folate and Vitamin B12?

Life Extension BioActive Folate & Vitamin B12 delivers two essential nutrients in their most biologically active forms. Folate is provided as 5-MTHF (5-methyltetrahydrofolate), the form your body can uses immediately without conversion. Vitamin B12 comes as methylcobalamin, the coenzyme form that supports neurological function and methylation. Together, these active B vitamins play a centre role in DNA synthesis, red blood cell formation, and homocysteine metabolism. By bypassing the need for enzymatic conversion, this formula is especially effective for individuals with genetic variations (like MTHFR) that impair the uses of synthetic folic acid and cyanocobalamin. Each capsule provides 1,000 mcg of folate (as 5-MTHF) and 500 mcg of vitamin B12 (as methylcobalamin), offering targeted support for heart, brain, and gastrointestinal health.

Who Can Benefit from This Supplement?

This supplement is ideal for anyone looking to optimise their B vitamin status, particularly those with increased needs or reduced absorption. Vegans and vegetarians often lack dietary B12, making this a practicable choice. Older adults experience declining stomach acid and intrinsic factor, reducing B12 absorption from food. Individuals with MTHFR gene variants may struggle to convert folic acid into active folate, so 5-MTHF bypasses that bottleneck. People with digestive conditions such as Crohn's, coeliac disease, or atrophic gastritis may also benefit from a pre-activated form. Additionally, those seeking to maintain healthy homocysteine levels for cardiovascular wellbeing will find this combination valuable. Pregnant or breastfeeding women often require extra folate, and the bioactive form supports maternal health without the risk of unmetabolised folic acid buildup.

How to Take BioActive Folate & Vitamin B12

For best results, take one capsule daily with or without food, preferably with a meal to enhance absorption. Swallow whole with water. This formula is suitable for vegetarians and is free from gluten, non-GMO, and manufactured in the USA with globally sourced ingredients. Store in a cool, dry place away from direct sunlight. As with any dietary supplement, consult your health care provider before uses, especially if you have a medical condition, are taking medication, or are pregnant or nursing. Do not exceed the recommended dosage. This product is intended to supplement the diet and should not be used as a substitute for a varied, balanced diet and healthy lifestyle.

Frequently Asked Questions

Can I take this with other B vitamins?

Yes, this formula complements other B vitamins. Many people take it alongside a B-complex supplement, but check total B12 and folate intake to avoid excessive amounts.

Is this product vegan?

Yes, the capsules are vegetarian (cellulose-based) and the ingredients are vegan-friendly.

What is 5-MTHF?

5-MTHF stands for 5-methyltetrahydrofolate, the active form of folate that the body uses directly. It avoids the conversion step required by folic acid, making it beneficial for those with MTHFR gene variants.

Can I take this on an empty stomach?

While generally well tolerated, some people experience mild stomach upset. Taking with food may help.

How long does one bottle last?

Each bottle contains 90 capsules. At one capsule per day, it provides a three-month supply.

This product is a food supplement and should not be used as a substitute for a varied, balanced diet and healthy lifestyle. Always consult a health care professional before taking any supplement.