Life Extension High Potency Optimised Folate – L-Methylfolate – 8500 mcg DFE – 30 Tablets

What Is Optimised Folate?

Life Extension High Potency Optimised Folate provides 8500 mcg DFE of L-methylfolate (5-MTHF), the naturally active form of vitamin B9. Unlike synthetic folic acid, which the body must convert, 5-MTHF is ready for immediate uses—making it an ideal choice for people with MTHFR gene variants that hinder conversion. This potent supplement delivers a generous dose of folate to support essential bodily functions.

Folate: Health Benefits Approved by EFSA

Folate contributes to normal homocysteine metabolism, promoting cardiovascular health by helping maintain healthy homocysteine levels already within the normal range. It also supports normal psychological function, red blood cell formation, and the reduction of tiredness and fatigue. Furthermore, maternal folate intake increases maternal folate status; low maternal folate status is a risk factor for neural tube defects in the developing foetus.

Who Should Consider This Supplement?

This product may be especially useful for women planning a pregnancy or during pregnancy, as adequate folate is essential for foetal development. Individuals with MTHFR gene variations who cannot efficiently convert folic acid may benefit from L-methylfolate. Those seeking to support cardiovascular and cognitive health as part of a healthy lifestyle may also find it valuable. Always consult a health care professional before starting any new supplement regimen.

Folic Acid vs L-Methylfolate: What’s the Difference?

Folic acid is the synthetic form of vitamin B9 found in many supplements and fortified foods. To be utilised, it must be converted into L-methylfolate (5-MTHF) through several enzymatic steps. However, a common genetic variation in the MTHFR gene reduces conversion efficiency for many people. L-methylfolate bypasses this step, providing the active form directly. This makes it a preferred choice for those with known MTHFR variants or anyone seeking a more bio-available folate.

Dosage Guide: How Much Folate Do You Need?

Life Extension Optimised Folate supplies 8500 mcg DFE (Dietary Folate Equivalents) per serving, a high-potency dose. For reference, the UK Reference Nutrient Intake (RNI) for folate is 200 µg per day for adults, with an additional 100 µg recommended during pregnancy. The safe upper limit for folic acid from supplements is 1,000 µg (1 mg) per day. Because this product contains L-methylfolate, the DFE conversion accounts for its higher bioavailability. Follow the recommended serving size unless advised otherwise by a health care provider.

Quality You Can Trust

Life Extension prioritises purity and potency. This supplement is non-GMO, gluten-free, and suitable for vegetarians. Manufacturing takes place in the USA, and a Certificate of Analyse is available for every batch. The brand is committed to using scientifically studied ingredients and dosages, ensuring you receive a product backed by research.

Frequently Asked Questions

Can I take this if I have an MTHFR mutation?

Yes, L-methylfolate is especially beneficial for individuals with MTHFR gene variants because it does not require conversion. However, consult your health care provider for personalized advice.

Is this product safe during pregnancy?

Folate is crucial during pregnancy for neural tube development. This product provides a high-dose; it is recommended to discuss the appropriate amount with your doctor, as prenatal needs vary.

How should I take this supplement?

The recommended serving is one tablet daily with or without food. Do not exceed the suggested uses without medical guidance.

These statements have not been evaluated by the Medicines and Health care products Regulatory Agency (MHRA). This product is not intended to diagnose, treat, or prevent any disease.

Adequate folic acid intake during pregnancy may reduce the risk of neural tube defects. The Department of Health advises that pregnant women should take a daily supplement of 400 µg folic acid until the 12th week of pregnancy. This product provides a higher dose; consult your health care professional.