Designs for Health Methylated B Complex - 120 Capsules

Key Ingredients & Methylated Forms

This comprehensive B complex delivers most B vitamins in their coenzymated or methylated forms, meaning they are ready for your body to use without extra conversion. Vitamin B12 is provided as methylcobalamin, the naturally occurring bioactive form that the brain and nervous system can utilise straight away. Folate comes as Quatrefolic, a highly stable and bioavailable (6S)-5-methyltetrahydrofolate glucosamine salt, ideal for those with MTHFR variants who cannot efficiently process folic acid. Vitamin B6 is included as pyridoxal-5-phosphate (P-5-P), the active coenzyme for neurotransmitter synthesis and homocysteine metabolism. The formula also contains B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), and B7 (biotin) to round out support for energy production and metabolic health.

How to Take This Supplement

Take one capsule daily with a meal to improve absorption and minimise any stomach upset. It is best taken in the morning or early afternoon, as B vitamins can be energising and may interfere with sleep if taken later in the day. This product is designed for long-term daily use, but we recommend consulting your health care professional before starting any new supplement regimen.

Benefits of Methylated B Complex

Taking a high-quality B complex with methylated forms supports methylation—a key process for DNA repair, detoxification, and neurotransmitter balance. Users often report feeling more energetic, experiencing clearer mental focus, and enjoying a more stable mood.* B vitamins also help maintain healthy homocysteine levels, which is important for cardiovascular health.* For individuals with MTHFR gene variants, methylated forms like methylfolate and methylcobalamin bypass common genetic blocks, making this formula particularly effective. The addition of trimethylglycine (TMG) and choline further supports methylation pathways, enhancing the bioavailability of the B vitamins.

Choosing the Right B Complex

When selecting a B complex, look for products that use active, methylated forms—especially if you have a known MTHFR polymorphism or experience fatigue despite a healthy diet. Transparent labelling that specifies the exact form and dosage of each B vitamin is essential. Designs for Health Methylated B Complex is vegan, non-GMO, and free from gluten, dairy, and soy, making it suitable for most dietary preferences. It is the #1 practitioner supplement brand recommended by functional medicine professionals, reflecting its quality and clinical trust.*

FAQ

Is this B complex suitable for vegans?
Yes, the capsules are vegan and contain no animal-derived ingredients.

Can I take this with other supplements?
Generally yes, but we advise spacing it at least two hours apart from high-dose vitamin C or antibiotics to optimise absorption.

How long until I notice effects?
Many people report improved energy and mental clarity within the first few weeks, but individual results vary.

Does this product contain folic acid?
No, it use methylated folate (Quatrefolic), which is the active form.

Side Effects and Interactions

B vitamins are generally safe and well-tolerated at recommended doses. High amounts of B3 (niacin) may cause temporary flushing or itching, and prolonged excessive intake of B6 can lead to nerve symptoms. A harmless bright yellow discolouration of urine is common from riboflavin (B2). If you are taking medications, particularly for Parkinson's disease, epilepsy, or chemotherapy, consult your doctor, as B vitamins can interact with certain drugs.

This product is a food supplement and should not be used as a substitute for a varied and balanced diet. Always consult your health care professional before taking any supplement.