Methylated B Complex Vitamins - Quatrefolic Folate, Methylcobalamin B12, TMG - 120 Capsules

Key Ingredients & Forms

What sets this supplement apart is its commitment to using clinically studied, bio-available forms. Let's break down the key ingredients:

• Vitamin B2 (Riboflavin) – 25 mg: Supports energy metabolism and acts as an antioxidant. This is a standard, well-absorbed form.
• Vitamin B6 (Pyridoxine) – 15 mg: Involved in over 100 enzymatic reactions, including amino acid metabolism and neurotransmitter production.
• Folate (as Quatrefolic® 5-MTHF) – 3400 µg DFE: This is the active, methylated form of folate. Unlike folic acid, which requires conversion in the body, 5-MTHF is ready for immediate uses—especially beneficial for those with MTHFR mutations.
• Vitamin B12 (as Methylcobalamin and Adenosylcobalamin) – 1000 µg: Two coenzyme forms of B12. Methylcobalamin is critical for methylation and neurological health, while adenosylcobalamin is stored in the mitochondria and supports energy production.
• TMG (Trimethylglycine, also known as Betaine) – 650 mg: A methyl donor that works alongside methylfolate and methylcobalamin to support homocysteine metabolism and liver function.

This formula is free from common allergens: no gluten, wheat, soya, corn, yeast, animal products, nuts, or artificial additives. It is also manufactured in an NSF-certified facility in the USA, adhering to strict cGMP guidelines.

What is B-Complex?

B-Complex refers to the group of eight essential B vitamins that work synergistically to support numerous bodily functions. These water-soluble vitamins—B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin)—play critical roles in energy metabolism, nervous system function, red blood cell formation, and DNA synthesis. Because the body cannot store them in large amounts, regular intake through diet or supplementation is necessary. A high-quality B-Complex supplement like this one provides a balanced ratio of these vitamins, often in their most bio-available forms, to help fill nutritional gaps and support overall wellness.

This particular formula goes a step further by utilising methylated forms of key B vitamins. Methylation is a biochemical process that affects everything from detoxification to mood regulation. For individuals with genetic variations like MTHFR, standard forms of folate and B12 may not be efficiently converted to their active forms, making methylated B-Complex an excellent choice for those seeking optimal absorption and utilisation.

Benefits of B-Complex

B vitamins are foundational to energy production. They help convert the food you eat into usable energy by acting as coenzymes in metabolic pathways. Riboflavin (B2), for instance, is essential for the metabolism of carbohydrates, fats, and proteins. Vitamin B6 supports neurotransmitter synthesis and homocysteine metabolism, while B12 and folate are crucial for red blood cell formation and neurological health.

Beyond energy, B-Complex plays a role in maintaining a healthy nervous system. Vitamins B1, B6, and B12 contribute to normal nerve function and may help support cognitive health as we age. The inclusion of TMG (trimethylglycine) in this formula further supports methylation and homocysteine balance, which is important for cardiovascular and brain health. Many users report feeling more vibrant and mentally clear when supplementing with a comprehensive B-Complex, especially one that uses active forms.

It is important to note that individual results vary, and these statements describe the general roles of B vitamins in the body, not specific therapeutic outcomes. Consistent uses as part of a balanced diet may help maintain normal energy levels and overall vitality.

How to Choose the Right B-Complex

Not all B-Complex supplements are created equal. When selecting one, consider the following factors:

• Methylated vs. Non-Methylated: If you have MTHFR variants or simply want the most bio-available forms, look for methylfolate (5-MTHF) and methylcobalamin. This product contains both.
• Dosage: Check that the amounts align with your needs. This formula provides high doses of B12 (1000 µg) and folate (3400 µg DFE), which are well above the Daily Value but typical for therapeutic support. B6 and B2 are present in moderate amounts.
• Purity: Avoid fillers, flow agents, and unnecessary additives. This supplement is free from those and is third-party tested.
• Certifications: Look for manufacturing in cGMP-compliant facilities. This product is made in the USA in an NSF-certified plant.
• Dietary Preferences: Suitable for vegans and vegetarians as it contains no animal products.

Always consult with a GP before starting any new supplement, especially if you are pregnant, nursing, or taking medications.

How to Take B-Complex

For best results, take one capsule daily with food and a full glass of water. Taking B vitamins with a meal can help reduce the chance of stomach upset and improve absorption. Some people prefer taking B-Complex in the morning, as the energy-supporting effects may interfere with sleep if taken too late in the day.

Each bottle contains 120 capsules, which is a 4-month supply at the recommended serving. Store in a cool, dry place away from direct sunlight. Do not exceed the recommended dose unless advised by a doctor.

Side Effects and Interactions

B vitamins are generally safe and well tolerated. However, high doses may cause mild side effects such as nausea, headache, or diarrhoea. A common and harmless effect of B-Complex supplementation is bright yellow urine, caused by excess riboflavin being excreted. This is normal and not a cause for concern.

Individuals taking certain medications—such as those for Parkinson's disease (levodopa), anticonvulsants, or chemotherapy drugs—should consult their doctor before using a high-dose B-Complex. TMG in high amounts may lower homocysteine significantly, which could be beneficial but needs monitoring. If you have kidney disease or are prone to kidney stones, discuss with your health care provider because of the B6 content.

This product is not intended to diagnose, treat, , or prevent any disease. If you experience any adverse reactions, discontinue uses and consult a medical professional.

Frequently Asked Questions

Who should consider a methylated B-Complex?

Anyone looking to support energy metabolism, methylation, and overall health, particularly those with MTHFR gene variants or who have difficulty absorbing standard forms of B12 and folate. It is also popular amongst individuals with high stress levels, athletes, and older adults.

Can I take this with other supplements?

Yes, but be mindful of total B vitamin intake from all sources. If you already take a Multivitamin or other B-containing supplements, check the cumulative dosage to avoid exceeding tolerable upper intake levels, especially for B6 (100 mg/day is considered safe for most adults).

Is this product vegan?

Yes. The capsules are free from animal products, and the ingredients are derived from non-animal sources.

How long does it take to notice effects?

Individual experiences vary. Some people report increased energy and mental clarity within a few days, while others may take several weeks. Consistency is key, and results depend on baseline nutritional status.

Does it contain any artificial ingredients?

No. The formula is free from artificial preservatives, sweeteners, colours, and flow agents. It is also non-GMO and gluten-free.

Disclaimer: Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, , or prevent any disease.