Natural Factors BioCoenzymated Methylfolate 1000 mcg, 60 Tablets

Key Benefits of Methylfolate and B12

Discover Natural Factors Biocoenzymated — Homocysteine Metabolism: Methylfolate and methylcobalamin help maintain normal homocysteine levels, supporting cardiovascular wellness.*
Psychological Function: Both nutrients contribute to normal psychological function and neurotransmitter synthesis.*
Blood Formation: Folate and B12 are needed for normal blood cell formation, aiding oxygen transport.*
Energy Release: Vitamin B12 contributes to normal energy-yielding metabolism.*
Immune System: Methylation processes support normal immune function.*

Who Should Consider a Methylfolate Supplement?

Those with MTHFR gene variations cannot efficiently convert folic acid, making active methylfolate essential. Individuals with elevated homocysteine, vegans and vegetarians (who often lack dietary B12), and older adults with reduced absorption may also benefit. This supplement is suitable for anyone aiming to support cardiovascular and neurological health through proper methylation.*

What Is Methylfolate and Why Is It Important?

Methylfolate, or 5-methyltetrahydrofolate (5-MTHF), is the biologically active form of folate. Unlike folic acid, it requires no conversion and is ready for immediate uses—critical for people with MTHFR mutations. Natural Factors BioCoenzymated Methylfolate delivers 1,000 mcg of this essential nutrient alongside methylcobalamin B12 to support methylation, a process vital for DNA synthesis, detoxification, and cellular energy.*

What Makes BioCoenzymated Methylfolate Special?

Natural Factors uses patented Quatrefolic® methylfolate, a highly stable and bio-available form. The addition of methylcobalamin (active B12) ensures synergistic action. This product is non-GMO, gluten-free, and vegetarian, with no artificial preservatives, colours, or sweeteners. It is manufactured in a GMP-certified facility owned by Natural Factors, guaranteeing quality control from raw material to finished product.

How to Uses This Supplement for Best Results

Chew or dissolve one tablet daily in the mouth before swallowing, or as directed by a health care professional. The sublingual route enhances absorption of methylcobalamin. For optimal methylation support, take consistently with meals. Do not exceed the recommended dose unless advised by a doctor.

Frequently Asked Questions

Can I take this if I have the MTHFR mutation?

Yes, this supplement provides the active folate that bypasses the MTHFR conversion step, making it ideal for those with genetic variations.

Is it safe to take 1000 mcg of methylfolate daily?

The safe upper level for folate from supplements is 1000 mcg per day; this product meets that threshold. Higher doses should only be used under medical supervision.

Does this contain folic acid?

No, it contains methylfolate (Quatrefolic®) and methylcobalamin—both are active forms, not synthetic folic acid or cyanocobalamin.

• Supports normal homocysteine metabolism, psychological function, and energy release*
• Active methylated forms: methylfolate (1,000 mcg) and methylcobalamin B12
• Ideal for MTHFR genetic variations
• Non-GMO, gluten-free, vegetarian
• No artificial preservatives, colours, or sweeteners
• Chewable or dissolvable tablet for enhanced absorption

Usage: Chew or dissolve 1 tablet daily in the mouth before swallowing or as directed by a health care professional. Store in a cool, dry place. Always read the label and follow directions for uses.

Disclaimer: This product is a food supplement. The statements made are in line with EFSA-approved health claims. This product is not intended to diagnose, treat, or prevent any disease.