NOW Foods, Methyl Folate, 1,000 mcg, 90 Tablets

Methyl Folate vs Folic Acid: Understanding the Difference

Many people turn to folic acid supplements to meet their folate needs, but did you know that folic acid requires conversion by the MTHFR enzyme to become active? For those with common genetic variations, this conversion is often inefficient. Enter methyl folate – the biologically active form that works straight away. Folic acid is the synthetic form of folate used in most supplements and fortified foods. It must be converted to 5-MTHF by the MTHFR enzyme before the body can uses it. Methyl folate, on the other hand, is already in the active form, requiring no conversion. This makes it a superior choice for individuals with common MTHFR polymorphisms (C677T, A1298C) that reduce conversion efficiency. Additionally, high doses of folic acid can lead to unmetabolised folic acid in the bloodstream, whereas methyl folate is directly utilised.

What Is Methyl Folate?

Methyl folate, also known as 5-methyltetrahydrofolate (5-MTHF), is the biologically active form of folate. Unlike synthetic folic acid, methyl folate does not require conversion by the MTHFR enzyme, making it directly available for the body to uses. This is especially important for individuals with MTHFR gene variants, who may have difficulty converting folic acid into its active form. Each tablet of NOW Foods Methyl Folate provides 1,000 mcg of this body-ready folate, delivered as (6S)-5-MTHF glucosamine salt for optimal absorption and efficacy.

Key Benefits of Methyl Folate

As the active form of folate, methyl folate plays a crucial role in several bodily functions. According to the European Food Safety Authority (EFSA), folate contributes to:

• Normal homocysteine metabolism
• Normal red blood cell formation
• Normal amino acid synthesis
• Normal blood formation
• Maternal tissue growth during pregnancy

By providing the active form directly, NOW Foods Methyl Folate supports these processes without relying on the body's ability to convert folic acid.

Who Should Consider Methyl Folate?

Methyl folate is particularly beneficial for:

• Women planning pregnancy or during pregnancy: Adequate folate intake is essential for foetal development. Methyl folate may be especially useful for those with MTHFR gene variants who cannot efficiently convert folic acid.
• Individuals with MTHFR gene mutations: Up to 40% of the population may have reduced MTHFR activity. Methyl folate bypasses this conversion step.
• Those concerned about homocysteine levels: Methyl folate helps maintain healthy homocysteine metabolism, supporting cardiovascular health.
• Anyone preferring an active folate source: For those who want the most bio-available form of folate.

How to Choose a Quality Methyl Folate Supplement

NOW Foods is a trusted brand committed to quality. Their Methyl Folate supplement is:

• Third-party tested for purity and potency
• Non-GM, vegan, and gluten-free
• Manufactured in GMP-certified facilities
• Free from common allergens like soya, dairy, and eggs

Choosing a supplement that provides the active form (5-MTHF) ensures maximum bioavailability, especially for those with MTHFR variants.

Suggested Dosage and Usage

Take one (1) tablet daily with food. Each tablet provides 1,000 mcg (1 mg) of methyl folate. This dosage falls within the recommended daily intake for adults and is commonly used during pregnancy. Do not exceed the recommended dose unless directed by a health care professional. As with any supplement, consult your health care practitioner before uses, especially if you are pregnant, nursing, or taking medication. Always read the label and follow directions for uses.

Potential Precautions

Methyl folate is generally well tolerated, but high doses may mask a vitamin B12 deficiency. If you have pernicious anaemia or suspected B12 deficiency, consult your doctor. Do not uses this product as a substitute for a varied and balanced diet. Keep out of reach of children. The tolerable upper intake level for folate from supplements is 1,000 mcg per day; this product provides exactly that amount, so do not combine with other high-dose folate supplements unless advised.

Frequently Asked Questions

Can I take methyl folate during pregnancy?

Yes, methyl folate is commonly recommended during pregnancy for foetal development. However, always consult your health care provider for personalized advice.

Is this product gluten-free?

Yes, NOW Foods Methyl Folate is certified gluten-free.

What is the difference between Quatrefolic and methyl folate?

Quatrefolic is a brand of (6S)-5-MTHF glucosamine salt. NOW Foods uses a similar high-quality form of methyl folate. Both are active folate.

How long does one bottle last?

With 90 tablets at one per day, each bottle provides a 90-day supply.

Food supplements should not be used as a substitute for a varied and balanced diet. This product is not intended to diagnose, treat, , or prevent any disease.