NOW Foods UC-II Type II Collagen with Undenatured Type II Collagen, 120 Vegetable Capsules

Why Undenatured Type II Collagen Matters

Collagen is the most abundant protein in the body, but not all collagen supplements are created equal. Undenatured type II collagen (UC-II) differs from hydrolysed collagen in several important ways:

• Structural integrity: The native triple-helix structure is preserved, which is thought to be key for its biological activity.
• Mechanism of action: UC-II works through a process called oral tolerance, where the immune system becomes less reactive to joint tissue, potentially reducing inflammation and supporting cartilage maintenance.*
• Low dosage: Clinical studies uses only 40 mg per day of UC-II, compared to several grammes of hydrolysed collagen for different outcomes.

This targeted approach makes UC-II a concentrated and efficient option for joint support.

Key Benefits of UC-II® Collagen for Joint Health

Joint discomfort and stiffness can affect daily activities. UC-II collagen may help maintain joint flexibility and comfort by supporting the body's natural joint renewal processes.* Cartilage, the connective tissue that cushions joints, relies on type II collagen as its primary structural protein. Undenatured type II collagen provides the building blocks that cartilage needs to stay resilient.

• Supports joint comfort and flexibility: Clinical studies suggest that 40 mg of UC-II per day may help reduce joint discomfort associated with normal activity.*
• Promotes healthy cartilage: As the principal protein in cartilage, type II collagen contributes to the tensile strength and toughness of the tissue.*
• Works with the immune system: Undenatured collagen interacts with immune cells in the gut-associated lymphoid tissue (GALT) to help regulate the body's response to joint stress.*

These benefits make UC-II a popular choice for active individuals, older adults, and anyone looking to maintain an active lifestyle.

What Is UC-II® Type II Collagen?

If you're looking to maintain active joints as you get older, UC-II® might be the targeted support you need. UC-II® is a patented form of undenatured (native) type II collagen sourced from chicken sternum cartilage. Unlike hydrolysed collagen, which is broken down into smaller peptides, UC-II retains its original triple-helix structure. This unique form is designed to work with the body's immune system to support healthy joint function.* Each capsule provides 40 mg of UC-II, a dosage shown in human clinical studies to promote joint comfort and mobility.

UC-II is not a Multivitamin or a general collagen blend—it is a targeted ingredient specifically researched for joint health. The manufacturing process is gentle to preserve the native collagen structure, ensuring the product delivers the active form used in clinical research.

Who Can Benefit from UC-II® Type II Collagen?

UC-II collagen is suitable for a wide range of adults seeking joint support. It is particularly beneficial for:

• Active adults and athletes: Regular exercise can place stress on joints. UC-II may help preserve joint comfort and range of motion.*
• Older adults: Natural ageing can lead to reduced cartilage integrity. Supplementing with undenatured type II collagen may support joint health as part of a healthy ageing regimen.*
• Individuals with occasional joint discomfort: Those who experience mild joint stiffness or achiness from daily activities may find relief with consistent uses of UC-II.*

Always consult a health care professional before starting any new supplement, especially if you have a known allergy to chicken products (UC-II is derived from chicken sternum).

How to Choose a Collagen Supplement for Joint Support

When selecting a collagen supplement for joints, consider the type of collagen and its form. Here are key factors to evaluate:

• Type of collagen: Type II collagen is specifically found in cartilage and is the most relevant for joint health. Hydrolysed collagen (types I and III) primarily supports skin and hair, while UC-II is specialised for joints.
• Undenatured vs. hydrolysed: Undenatured collagen retains its native structure, which is believed to be important for its immune-modulating effects. Hydrolysed collagen is broken down and absorbed differently.
• Dosage and clinical evidence: Look for dosages used in human studies. UC-II has been studied at 40 mg per day, which is the amount in each capsule of this product.
• Quality and purity: Choose supplements that are non-GM, free from common allergens, and manufactured in GMP-certified facilities. NOW Foods UC-II is made without gluten, soya, dairy, eggs, nuts, and is non-GM.
• Third-party testing: GMP certification and NPA A-rated verification ensure that the product meets quality standards for potency and purity.

FAQs About UC-II® Type II Collagen

How long does it take to see results?

Individual results vary. Some users may notice improvements in joint comfort within a few weeks, while others may require consistent uses for 2–3 months to experience full benefits. Clinical studies often last 30–90 days.

Can UC-II be taken with other supplements?

Yes, UC-II can be taken alongside other supplements, including multivitamins and omega-3s. However, if you take medications or have health conditions, consult your health care provider.

Is UC-II safe for vegetarians or vegans?

No, UC-II is derived from chicken sternum cartilage, making it unsuitable for vegetarian or vegan diets. However, the capsules are vegetable-based (hypromellose).

Are there any side effects?

UC-II is generally well tolerated. As with any supplement, some individuals may experience mild digestive discomfort. Stop uses and consult a doctor if you have an adverse reaction.

*These statements have not been evaluated by the Medicines and Health care products Regulatory Agency (MHRA). This product is not intended to diagnose, treat, , or prevent any disease.