NutriCology TMG (Trimethylglycine) 750 mg, 100 Vegetarian Capsules

Why Consider TMG Supplementation?

Trimethylglycine (TMG) is a naturally occurring compound that plays an essential role in methylation, a process vital for DNA synthesis, detoxification, and energy production. By donating methyl groups, TMG helps convert homocysteine back into methionine, thereby contributing to normal homocysteine metabolism* — a factor recognised by the European Food Safety Authority (EFSA) as important for cardiovascular and liver health. Additionally, TMG aids in maintaining normal liver function and supports the body's natural detoxification pathways.*

For individuals with genetic variations like MTHFR or those seeking to optimise their methylation cycle, TMG offers a direct and efficient source of methyl groups that bypasses the folate cycle. This makes it a valuable supplement for supporting overall wellbeing.

What Is Trimethylglycine (TMG)?

TMG, also known as betaine, is a derivative of the amino acid glycine. It is found naturally in small amounts in foods such as beetroot, spinach, and whole grains. Chemically, it contains three methyl groups, which are transferred in methylation reactions. Unlike some synthetic alternatives, NutriCology TMG is derived from natural sources and manufactured to high purity standards, delivering 750 mg per capsule.

This concentrated form ensures you get a potent dose in a convenient vegetarian capsule, making it easy to incorporate into your daily routine.

How to Take NutriCology TMG

The recommended serving is one capsule per day, taken with a meal to enhance absorption. Some individuals may benefit from splitting the dose into two capsules, but it is advisable to start with one and assess tolerance. As with any supplement, consult a health care professional before use, especially if you are pregnant, nursing, or taking medication.

TMG can be taken alongside other methylation-supporting nutrients like methylated B vitamins (e.g., methylfolate and methylcobalamin) and vitamin B6. This combination may offer synergistic benefits for homocysteine metabolism and overall methylation status. However, do not exceed the recommended dose, as excessive intake may occasionally cause mild digestive discomfort.

Why Choose NutriCology TMG?

NutriCology, part of the Allergy Research Group family, has been a trusted name in nutritional supplements for over 45 years. This TMG product stands out for its high-strength 750 mg dose per capsule, each made with vegetarian and hypoallergenic ingredients. The formula is free from gluten, dairy, soy, corn, nuts, eggs, shellfish, fish, sesame, and yeast, with no artificial additives, binders, or fillers.

Every batch is produced in a GMP-certified facility and undergoes rigorous testing for purity and potency. This commitment to quality ensures you receive a reliable and effective product every time, backed by decades of scientific research and clinical experience.

Ingredients and Purity

Each serving (one capsule) contains: Trimethylglycine (anhydrous betaine) 750 mg. Other ingredients: Hypromellose (vegetable capsule), microcrystalline cellulose, silicon dioxide, magnesium stearate (vegetable source). This product is free from common allergens and is suitable for vegetarians and vegans. It is also hypoallergenic, making it ideal for individuals with sensitivities.

*These statements have not been evaluated by the Medicines and Health care products Regulatory Agency (MHRA). This product is not intended to diagnose, treat, or prevent any disease.

Frequently Asked Questions About TMG

What is the difference between TMG and DMG?

Trimethylglycine (TMG) has three methyl groups, while dimethylglycine (DMG) has two. TMG donates one methyl group to become DMG, which is then further metabolised. Both play roles in methylation, but TMG is more directly involved in homocysteine conversion.

Can I take TMG if I have a MTHFR mutation?

Yes, TMG is often recommended for individuals with MTHFR mutations because it provides an alternative methylation pathway that bypasses the folate cycle. This can help support homocysteine metabolism even when the MTHFR enzyme is less active.

Is TMG safe for long-term use?

When taken at the recommended dose, TMG is generally considered safe for long-term use. However, it is wise to review your supplement regimen periodically with a health care professional to ensure it continues to meet your needs.