Klaire Labs SFI Health P-5-P – Bioactive Vitamin B6 (Pyridoxal-5-Phosphate) – 30 mg, 250 Vegetarian Capsules

Why Choose Klaire Labs P-5-P?

Not all vitamin B6 supplements are created equal. Klaire Labs has earned the trust of health care professionals with its commitment to hypoallergenic, practitioner-tested formulations. This product is designed for individuals with sensitivities or those following strict dietary protocols.

• Hypoallergenic Formula: Free from milk, casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, corn, and yeast. No artificial colours, flavours, or preservatives.
• Vegetarian Capsules: Made from plant-based materials, suitable for vegans and vegetarians.
• Practitioner Trust: Developed with input from clinicians and used by practitioners for decades.
• Convenient Dosage: Each capsule provides 30 mg – a therapeutic amount for targeted support. The 250-capsule bottle offers a long-lasting supply.

What Is Pyridoxal-5-Phosphate (P-5-P)?

Vitamin B6 occurs in several forms, but pyridoxal-5-phosphate (P-5-P) is the most biologically active. It serves as a coenzyme for over 100 enzymes involved in amino acid, carbohydrate, and lipid metabolism. Unlike the more common supplement form, pyridoxine HCl, P-5-P does not require conversion in the liver. This makes it particularly valuable for individuals with liver conditions, genetic polymorphisms (such as MTHFR), or those seeking maximum bioavailability.*

Klaire Labs SFI Health P-5-P delivers 30 mg of this active coenzyme per capsule in a hypoallergenic vegetarian formula. Trusted by health care professionals since 1969, Klaire Labs emphasises purity and potency, ensuring each batch meets rigorous quality standards.

How Is P-5-P Different from Regular Vitamin B6?

Standard vitamin B6 supplements usually contain pyridoxine HCl (PN), which must be converted to P-5-P by the liver. This conversion involves two enzymatic steps and can be inefficient in some people due to genetic variations (e.g., in the enzyme pyridoxal kinase) or liver impairment. In contrast, P-5-P is the final active form, bypassing these conversion steps. Research suggests that P-5-P may be better absorbed and retained in the body, making it a preferred choice for those seeking enhanced bioavailability.*

Health Benefits of Bioactive Vitamin B6

The body relies on P-5-P for a wide range of physiological processes. Here are some of the key areas where this coenzyme makes a difference:

• Energy Production: Vitamin B6 contributes to normal energy-yielding metabolism, helping to sustain energy levels throughout the day.*
• Cardiovascular Health: It works with folate and vitamin B12 to support normal homocysteine metabolism, thereby maintaining healthy homocysteine levels.* Elevated homocysteine is a known risk factor for cardiovascular issues.
• Neurotransmitter Synthesis: This coenzyme contributes to normal psychological function and is required for the synthesis of serotonin, dopamine, norepinephrine, and GABA.*
• Immune Function: Vitamin B6 contributes to the normal function of the immune system, supporting a healthy immune response.*
• Hormonal Balance: By aiding in the metabolism of steroid hormones, P-5-P may help maintain hormonal equilibrium, particularly during the menstrual cycle.*
• Reduction of Tiredness and Fatigue: Vitamin B6 contributes to the reduction of tiredness and fatigue, making it valuable for overall vitality.*

These multifaceted roles make vitamin B6 a foundational nutrient for overall wellness. Choosing the active form ensures that your body can utilise it efficiently.*

Who Can Benefit from P-5-P?

While everyone needs vitamin B6, certain groups may particularly benefit from the active P-5-P form:

• Individuals with liver conditions or compromised liver function.
• Those with MTHFR or other genetic polymorphisms affecting methylation.
• People on medications that deplete B6, such as oral contraceptives or certain anticonvulsants.*
• Athletes and active individuals who require efficient energy metabolism.
• Older adults, as nutrient absorption and conversion may decline with age.

As always, consult a health care professional before starting any new supplement regimen.

Safety and Precautions

Vitamin B6 is generally well-tolerated. The tolerable upper intake level (UL) for adults is 100 mg per day. This product provides 30 mg per capsule, which is below the UL. However, long-term use of very high doses (over 200 mg daily) has been associated with peripheral neuropathy. If you experience any tingling or numbness, discontinue use and consult your doctor. This product is a food supplement and should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Keep out of reach of children.

These statements have not been evaluated by the Medicines and Health care products Regulatory Agency (MHRA). This product is not intended to diagnose, treat, , or prevent any disease.