ProHealth Nicotinamide Riboside Pro 500 | 60 Capsules | 500 mg NR + 250 mg TMG

Health Benefits of Nicotinamide Riboside Supplementation

NAD+ is a key coenzyme involved in cellular energy production, DNA repair, and the activation of sirtuins – proteins associated with longevity. By boosting NAD+ levels, nicotinamide riboside (NR) helps maintain mitochondrial function and supports healthy ageing.

• Cellular Energy: NR raises NAD+, which is essential for ATP synthesis in mitochondria. This may help reduce fatigue and sustain daily energy.
• Mitochondrial Support: Healthy mitochondria are vital for overall cell health. NR helps preserve mitochondrial efficiency, particularly as we grow older.
• Healthy Ageing: Declining NAD+ is linked to age-related changes. Supplementing with NR may support cellular resilience and graceful ageing.

These statements have not been evaluated by the European Medicines Agency. This product is not intended to diagnose, treat, or prevent any disease.

What Is Nicotinamide Riboside?

Nicotinamide riboside (NR) is a form of vitamin B3 that acts as a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme vital for cellular energy metabolism and DNA repair. As we age, NAD+ levels naturally drop, which can affect mitochondrial function and overall vitality. ProHealth Nicotinamide Riboside Pro 500 provides 500 mg of high-quality NR along with 250 mg of trimethylglycine (TMG) to support healthy NAD+ levels and sustainable energy production.

Nicotinamide Riboside vs. Niacin and Niacinamide

NR is a distinct type of vitamin B3, different from niacin (nicotinic acid) and niacinamide. Unlike niacin, NR does not cause the characteristic skin flush, making it easier to tolerate at higher doses. Niacinamide also avoids flushing but can inhibit sirtuin activity at high levels, whereas NR directly boosts NAD+ without this concern. Additionally, the inclusion of TMG supports methylation, helping to maintain methyl donor reserves used during NR conversion. This makes NR plus TMG a smart choice for long-term NAD+ support.

Recommended Dosage and How to Take Nicotinamide Riboside

The suggested serving is 2 capsules per day, preferably in the morning with food. Each serving provides 1,000 mg of NR and 500 mg of TMG. As with any supplement, start with a lower dose to assess tolerance. Consult a health care professional before undertake, especially if you are pregnant, nursing, or have a medical condition.

How to Choose a High-Quality Nicotinamide Riboside Supplement

Quality matters when selecting an NAD+ precursor product. ProHealth Nicotinamide Riboside Pro 500 is doctor-formulated and manufactured in the United States. Every batch undergoes third-party laboratory testing for purity and potency, with results published online. Look for products with transparent labelling and independent verification to ensure a safe and effective supplement.

Potential Side Effects and Safety Considerations

Nicotinamide riboside is generally well tolerated. Some individuals may experience mild digestive upset, nausea, or headache, particularly at higher doses. These effects often subside as the body adjusts. Because NR influences NAD+ metabolism, it may interact with certain medications. Always discuss supplementation with your GP. High-dose B3 supplements, including NR, should be used under medical guidance.

Frequently Asked Questions

What is the difference between NR and NMN?

Both are NAD+ precursors. NMN (nicotinamide mononucleotide) is one step closer to NAD+ but is larger and may require a transporter. NR is a smaller molecule that is efficiently converted to NAD+ inside cells. Research on both is ongoing, and NR has a long history of safety in human studies.

Can NR help with weight management?

While NR supports energy metabolism, it is not a weight-loss supplement. Some studies suggest it may support metabolic health, but individual results vary. A balanced diet and exercise remain key for weight management.

How long does it take to feel the effects of NR?

Some users report increased energy within a few weeks, but effects can vary. NAD+ levels typically rise with consistent supplementation, and benefits for cellular health are cumulative over months.

Is TMG necessary with NR?

TMG acts as a methyl donor. When NR is converted to NAD+, it consumes methyl groups. Adding TMG helps maintain methylation balance, supporting homocysteine metabolism and overall health. It is considered a complementary addition.

These statements have not been evaluated by the European Medicines Agency. This product is not intended to diagnose, treat, or prevent any disease.