Pure Encapsulations Folate 5,000 Plus - Activated Folate, Vitamin B12 and B6 Combination - 60 Capsules

Key Benefits of Folate, B12 and B6

These three B vitamins work together to support several important functions in the body. Here are some of the ways they may contribute to your health:*

• Cellular Health: Folate and vitamin B12 are essential for DNA synthesis and red blood cell formation. Adequate levels help maintain healthy cell division and growth.*
• Cardiovascular Support: By supporting the metabolism of homocysteine, an amino acid linked to heart health, these vitamins help maintain healthy endothelial function and promote normal homocysteine levels already within a healthy range.*
• Neurological Function: Vitamin B12 and folate are involved in the production of neurotransmitters and the maintenance of the myelin sheath, which protects nerve fibres. This may help support cognitive function and mood balance.*
• Energy Metabolism: B vitamins assist in converting food into energy, helping to reduce fatigue and support overall vitality.*

These benefits are supported by decades of research on the role of B vitamins in human health. While individual results may vary, incorporating these nutrients into a balanced diet can be a valuable part of a wellness routine.

What Is Activated Folate Plus?

Pure Encapsulations Folate 5,000 Plus combines three essential B vitamins in their most bio-available forms: 5,000 mcg of folate as 5-methyltetrahydrofolate (5-MTHF), the naturally occurring, active form of folate, along with activated vitamin B12 (as methylcobalamin) and vitamin B6 (as pyridoxal-5-phosphate). This formula is designed to support cellular health, cardiovascular function, and neurological wellness.*

Unlike synthetic folic acid, which requires enzymatic conversion in the body, 5-MTHF is already in its active form and can be used immediately by every cell. This makes it an ideal choice for individuals with genetic variations (such as MTHFR) that impair folate metabolism. Combined with methylcobalamin and pyridoxal-5-phosphate, this trio works synergistically to support key biochemical pathways, including homocysteine metabolism.*

Who May Benefit from This Formula?

This supplement is designed for individuals looking to support their B vitamin status, particularly those who may have higher needs or difficulty converting synthetic forms. It may be especially helpful for:*

• Individuals with MTHFR Variants: Genetic variations can reduce the body's ability to convert folic acid into active folate. Using 5-MTHF bypasses this step.*
• Adults Over 50: Ageing can reduce absorption of vitamin B12 from food, making supplementary forms like methylcobalamin beneficial.*
• Vegans and Vegetarians: Since B12 is primarily found in animal products, plant-based eaters may need extra support from activated B12.*
• Those Concerned with Heart Health: Maintaining healthy homocysteine levels is important for cardiovascular wellness, and this formula directly supports that pathway.*

Always consult with a health care professional before starting any new supplement, especially if you have a medical condition or take medication.

Top Ingredients in This Formula

5-Methyltetrahydrofolate (5-MTHF): This is the biologically active form of folate, also known as methylfolate. It is naturally occurring in foods and is the form used directly by the body for methylation, DNA synthesis, and homocysteine metabolism. Unlike folic acid, 5-MTHF does not require conversion by the MTHFR enzyme, making it accessible to everyone.*

Vitamin B12 as Methylcobalamin: Methylcobalamin is the active coenzyme form of vitamin B12. It participates in methylation reactions and is crucial for nerve health, red blood cell production, and energy metabolism. Methylcobalamin is generally preferred over cyanocobalamin because it is retained better in the body.*

Vitamin B6 as Pyridoxal-5-Phosphate (P-5-P): This is the active form of vitamin B6. It serves as a cofactor for numerous enzymes involved in amino acid metabolism, neurotransmitter synthesis, and homocysteine breakdown. P-5-P is more readily utilised than pyridoxine HCl, especially in individuals with liver issues or certain genetic variations.*

Together, these three activated B vitamins work synergistically to support multiple aspects of health, from cardiovascular function to cognitive performance.*

How to Choose High-Quality B Vitamin Supplements

Not all B vitamin supplements are created equal. When selecting a high-quality product, consider the following factors:

Form of Nutrients: Look for active forms like 5-MTHF (folate), methylcobalamin (B12), and pyridoxal-5-phosphate (B6). These are ready for the body to uses without needing conversion. Synthetic forms (folic acid, cyanocobalamin, pyridoxine HCl) require additional metabolic steps and may not be suitable for everyone.

Purity and Allergen Information: Pure Encapsulations products are free from common allergens including wheat, gluten, soya, dairy, eggs, fish, shellfish, peanuts, tree nuts, and GMOs. They also contain no artificial colours, flavours, or preservatives.

Third-Party Testing: Pure Encapsulations supplements are manufactured in a GMP-certified facility and undergo rigorous testing for potency and purity. Each batch is verified to ensure what's on the label matches what's in the capsule.

Dosage: This formula provides 5,000 mcg of folate (as 5-MTHF), which is well above the recommended daily intake. This high-dose is often used to support healthy homocysteine levels and address specific nutritional needs. However, it is important to follow the recommended serving size and discuss with your health care provider.

FAQs About Activated Folate and B Vitamins

What is the difference between folic acid and 5-MTHF? Folic acid is a synthetic form of folate that must be converted in the liver into active 5-MTHF. This conversion process can be inefficient, especially for individuals with MTHFR gene mutations. 5-MTHF is already active, so it can be used directly by the body. Many experts recommend 5-MTHF for optimal support.*

Why are activated B vitamins better? Activated forms (methylcobalamin, pyridoxal-5-phosphate, and 5-MTHF) are the forms that your body actually uses. They do not need to be converted, which ensures that even people with genetic variations or health conditions can benefit. They are also less likely to cause buildup of unmetabolised synthetic vitamins in the blood.

How should I take this supplement? The recommended serving is one capsule per day, taken with a meal to enhance absorption. Swallow whole with water or as directed by your health care professional. Do not exceed the suggested dose unless advised by a doctor.

Can I take this with other supplements? This formula can be used alongside other supplements, but be mindful of total B vitamin intake. If you take a Multivitamin that already contains high doses of B vitamins, consider adjusting accordingly. Always consult a health care provider for personalized advice.

This product is a food supplement and should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. These statements have not been evaluated by the European Medicines Agency or the Medicines and Health care products Regulatory Agency (MHRA). This product is not intended to diagnose, treat, , or prevent any disease.