Thorne 5-MTHF - Methylfolate (Active B9 Folate) - 5 mg, 60 Capsules

Ever wondered why some folate supplements work better than others? The answer lies in bioavailability. Thorne's 5-MTHF delivers 5 mg of active methylfolate (as Quatrefolic®), the form your body can use straight away—no conversion needed. This makes it an excellent choice for those with MTHFR gene variants or anyone seeking a high-quality B9 supplement. With 60 capsules per bottle, it is a convenient two-month supply.

What Is the Difference Between Folic Acid and 5-MTHF?

Folic acid is the synthetic form found in many supplements and fortified foods. It requires successive enzymatic reductions to become active. 5-MTHF (methylfolate) is already in its active form, ready for your body to use directly. For individuals with reduced conversion capacity due to genetic variations such as MTHFR C677T, 5-MTHF is a preferable choice. Thorne’s product use the premium Quatrefolic® ingredient, a glucosamine salt of (6S)-5-MTHF that ensures high stability and absorption. This form is also less likely to mask vitamin B12 deficiency compared to high doses of folic acid.

Who Should Consider This Supplement?

Thorne 5-MTHF is suitable for individuals needing an active folate form, particularly those with MTHFR mutations, pregnant or nursing mothers, vegans, or anyone with increased folate requirements. It may also benefit older adults, athletes, and those supporting cardiovascular health or healthy ageing. People taking medications that interfere with folate metabolism, such as methotrexate, may also find it useful. Always consult a health care professional before starting any supplement, especially if you are pregnant, nursing, or have a medical condition.

Key Health Benefits of Methylfolate

Supplementing with active folate supports several aspects of health. It contributes to normal homocysteine metabolism, which is important for cardiovascular wellness. By helping maintain healthy homocysteine levels, 5-MTHF supports proper blood vessel and nerve function. For women of childbearing age, adequate folate intake contributes to normal maternal tissue growth during pregnancy, supporting foetal development. Additionally, 5-MTHF contributes to normal psychological function, affecting mood and cognitive health. The active form is particularly effective for those with conditions affecting folate absorption or conversion, such as gastrointestinal disorders or certain medications.

Recommended Dosage and Usage

Each serving is one capsule, providing 5 mg (5,000 mcg) of methylfolate. For most adults, this dose supports daily requirements. Pregnant women typically need 400–800 mcg daily, but higher doses may be recommended by a health care provider. Take with or without food, as directed. Do not exceed the stated recommended daily dose. The bottle contains 60 capsules, sufficient for 60 days when taken as directed. Store in a cool, dry place away from direct sunlight.

Why Choose an Active Folate Like 5-MTHF?

Folate is essential for DNA synthesis, red blood cell formation, and overall health. Many supplements contain synthetic folic acid, which must be converted in the body to its active form. Thorne’s 5-MTHF delivers biologically active folate directly, bypassing conversion. This is especially beneficial for individuals with MTHFR gene variants impairing folate metabolism. Each capsule provides 5 mg of Quatrefolic® (6S)-5-MTHF, a form known for stability and bioavailability. With 60 capsules per bottle, it offers a two-month supply at one capsule per day.

How to Choose a Quality Folate Supplement

Look for supplements using bioactive forms like 5-MTHF, third-party tested for purity and potency, and free from unnecessary additives. Thorne is renowned for quality, being the #1 most recommended clinical brand by health care practitioners (based on a 2026 independent survey). Their 5-MTHF is non-GMO, gluten-free, and contains no artificial preservatives. When selecting a supplement, consider certifications like NSF or USP, whilst Thorne's manufacturing standards exceed these requirements. The company also tests for heavy metals and microbial contaminants. With Thorne, you get a product trusted by over 100 professional sports teams.

Frequently Asked Questions

Can I take 5-MTHF instead of folic acid? Yes, 5-MTHF is a direct alternative for those needing active folate, especially if you have an MTHFR mutation.
Is 5 mg too high for daily use? The upper limit for folate from supplements is 1,000 mcg for most adults, but higher doses like 5 mg may be prescribed for certain conditions. Always follow your health care provider's advice.
Does this product contain allergens? Thorne 5-MTHF is free of gluten, dairy, soy, and other common allergens. It is suitable for vegetarians and vegans.
Why choose Thorne over other brands? Thorne is trusted by over 100 professional sports teams and is the #1 recommended clinical brand amongst health care practitioners, reflecting commitment to quality and efficacy.
Can this supplement be taken with other medications? It is generally safe, but if you are taking anticoagulants or other medications, consult your health care provider to avoid interactions.
How long will one bottle last? At one capsule per day, one bottle of 60 capsules lasts approximately two months.

*These statements have not been evaluated by the Medicines and Health care products Regulatory Agency (MHRA). This product is not intended to diagnose, treat, or prevent any disease. Food supplements should not be used as a substitute for a varied diet and healthy lifestyle.