THORNE Methyl-Guard - Supports Healthy Methylation* - 180 Capsules

Who Can Benefit from Methylation Support?

People with MTHFR gene variations often have difficulty converting synthetic folic acid into its active form. Methyl-Guard bypasses this step by supplying pre-methylated folate and B12. Vegans and vegetarians, who may have lower B12 intake, can also benefit from methylcobalamin. Older people, athletes, and those under physical stress may require additional methylation support. Thorne is trusted by more than 100 professional sports teams and is the number one most recommended clinical brand by consumers and health care practitioners (according to a 2026 independent survey), making it a preferred choice for those seeking high-quality methylation support.*

What Is Methyl-Guard and Why Does Methylation Matter?

Every cell in your body depends on methylation — a fundamental biochemical process that influences DNA synthesis, gene expression, neurotransmitter production, detoxification, and homocysteine regulation. If methylation pathways become compromised, it can affect cardiovascular, neurological, and skeletal health. THORNE Methyl-Guard is a targeted supplement designed to support optimal methylation by providing the most bioavailable forms of key nutrients: active folate (5-MTHF), active vitamin B12 (methylcobalamin), vitamin B6 (as pyridoxal 5'-phosphate), and betaine (trimethylglycine). These ingredients work together to promote healthy methylation and help maintain homocysteine levels already within a normal range.*

Key Benefits for Heart, Brain, and Bone Health

Maintaining healthy blood vessels and cardiovascular function relies on proper methylation. By facilitating homocysteine metabolism, Methyl-Guard supports arterial flexibility and heart function.* For the brain, active B vitamins are crucial for nerve cell communication and cognitive function. Additionally, methylation plays a role in bone metabolism, helping to maintain bone density and strength.* Each serving delivers 2 mg of 5-MTHF (as calcium folinate), 1 mg of methylcobalamin, 20 mg of vitamin B6 (as P-5-P), and 500 mg of betaine anhydrous — a comprehensive dose to support these vital processes.*

What Makes THORNE Methyl-Guard Special?

Not all B vitamin supplements are the same. Many contain synthetic folic acid and cyanocobalamin, which require enzymatic conversion and may not be effective for everyone. THORNE Methyl-Guard use only the active, methylated forms: 5-MTHF (calcium folinate) — the same form found in nature, and methylcobalamin — the coenzyme form of B12. Betaine acts as a direct methyl donor, and vitamin B6 as P-5-P is the active coenzyme form. The formula is free from gluten, dairy, and soy, and is manufactured in a cGMP-compliant facility. Third-party testing ensures purity and potency.

How to Choose a Methylation Support Supplement

When choosing a methylation supplement, there are several factors to consider. Firstly, ensure the folate and B12 are in their active forms (5-MTHF and methylcobalamin). Secondly, look for additional methyl donors like betaine or SAMe. Thirdly, check that vitamin B6 is in its active form (P-5-P). Next, select a product free from unnecessary additives and allergens. Finally, choose a reputable brand with transparent quality practises. THORNE meets all these criteria, offering a potent, well-absorbed formula in easy-to-swallow capsules.

Frequently Asked Questions About Methyl-Guard

What is the recommended dosage of Methyl-Guard?

Take 2 capsules daily with food. Each bottle of 180 capsules provides a 90-day supply. For optimal absorption, consume with a meal that contains some fat.

Can I take Methyl-Guard alongside other supplements?

Yes, it can be combined with other Thorne products. However, if you are taking medications, especially blood thinners, or have a medical condition, consult your health care practitioner before use.

Is Methyl-Guard suitable for vegans?

Yes. The capsules are made from hypromellose (vegetable cellulose) and the formula contains no animal-derived ingredients.

Does Methyl-Guard contain folic acid?

No. It contains calcium folinate (5-MTHF), the active form of folate, making it ideal for people with MTHFR gene variations.

*These statements have not been evaluated by the Medicines and Health care products Regulatory Agency. This product is not intended to diagnose, treat, , or prevent any disease.