XYMOGEN 5-MTHF ES - Bioactive Folate Food Supplement - 17,000 mcg (as Quatrefolic) - 60 Capsules

Why Choose 5-MTHF ES?

5-MTHF ES provides 17,000 mcg of Quatrefolic, a patented water-soluble form of bioactive folate that the body can uses straight away. Unlike synthetic folic acid, this active form does not require conversion by the MTHFR enzyme, making it an excellent choice for those with genetic variations. Folate contributes to normal red blood cell formation, homocysteine metabolism, and psychological function, as well as reducing tiredness and fatigue. During pregnancy, it supports maternal tissue growth and foetal development—all approved health claims by the European Food Safety Authority (EFSA).

Who Can Benefit from 5-MTHF ES?

This high-strength supplement is particularly useful for pregnant women or those planning a pregnancy, as folate requirements increase during this period. Individuals with MTHFR gene variants, who may have difficulty converting folic acid, will find the active form beneficial. Older adults, people with gastrointestinal absorption issues, and anyone seeking to support methylation for overall wellness may also consider it. Always consult a health care professional before starting a new supplement routine.

How to Uses 5-MTHF ES

Each bottle contains 60 capsules. The recommended serving is one capsule daily, delivering 17,000 mcg of bioactive folate. This amount exceeds the recommended dietary allowance (RDA) of 400 mcg for adults (600 mcg in pregnancy) due to its high bioavailability and suitability for those with increased needs or absorption challenges. Do not exceed the recommended dose unless advised by a doctor.

What Is 5-MTHF and How Is It Different?

5-MTHF (5-methyltetrahydrofolate) is the metabolically active form of folate, ready for immediate uses without hepatic conversion. Folic acid, by contrast, must be processed by the MTHFR enzyme, which can be inefficient in people with certain gene variants. XYMOGEN 5-MTHF ES uses Quatrefolic, a stable, water-soluble glucosamine salt of 5-MTHF that offers enhanced absorption and utilisation.

Selecting a Quality Folate Supplement

When choosing a folate supplement, prioritise the active form (5-MTHF) over synthetic folic acid. Look for third-party testing for purity and potency. XYMOGEN 5-MTHF ES is vegan, gluten-free, non-GMO, and free from common allergens such as dairy, soya, corn, peanuts, egg, and shellfish. The brand emphasises evidence-based formulations and partners with health care professionals. Always check the label and consult a qualified practitioner if you have specific health concerns.

Potential Side Effects and Precautions

Folate supplements are generally well tolerated. However, very high doses of folic acid may mask a vitamin B12 deficiency, but this risk is lower with active 5-MTHF. Nonetheless, ensure adequate B12 intake. The tolerable upper intake level for folic acid from supplements is 1,000 mcg per day; 5-MTHF may have a different safety profile. Consult a doctor before using high-dose folate, especially if you are on medication or have a medical condition. Food supplements should not replace a balanced diet and healthy lifestyle.

Frequently Asked Questions

Can I take 5-MTHF ES if I have the MTHFR gene mutation?

Yes. 5-MTHF ES contains the active form of folate, bypassing the MTHFR enzyme, making it suitable for those with MTHFR variants who may not efficiently convert folic acid.

Is this supplement safe during pregnancy?

Folate is crucial during pregnancy, and 5-MTHF ES provides a high-dose of bioactive folate. However, pregnant women should seek medical advice before taking any supplement to ensure it meets their specific needs.

What makes Quatrefolic different from other 5-MTHF forms?

Quatrefolic is a glucosamine salt of 5-MTHF that is water-soluble and highly stable, offering improved bioavailability compared to other forms, ensuring efficient absorption and uses by the body.

These statements have not been evaluated by the Medicines and Health care products Regulatory Agency (MHRA). This product is not intended to diagnose, treat, , or prevent any disease.